International Journal of Medical Science and Public Health, 10 (1), 40-45. Prevalence and characteristics of impaired awareness of hypoglycemia in King Fahad Medical City, Saudi Arabia. Int J Med Sci Public Health, 10 (1), 40-45. doi:10.5455/ijmsph.2021.03022202117032021Ībdul Aloriney (2021) Prevalence and characteristics of impaired awareness of hypoglycemia in King Fahad Medical City, Saudi Arabia. Key words: Hypoglycemia Impaired Awareness of Hypoglycemia Severe hypoglycemia DiabetesĪbdul Aloriney. Prospective investigations that concentrate particularly on restoring awareness of hypoglycemia are required to promote measures to manage this severe complication of insulin treatment. This remains to place them at risk of experiencing severe hypoglycemia.Ĭonclusion: IAH and severe hypoglycemia are relatively common among T1D and T2D patients. These findings are consistent with the hypothesis that IAH develops mostly in patients with type 1 diabetes (T1D) but also presented in type 2 diabetes (T2D). Results: Findings showed a low prevalence of IAH in the region (13.8%) and that IAH patients had experienced a significantly higher rate of severe hypoglycemia compared to hypoglycemic aware patients. Materials and Methods: This was an observational cross-sectional study conducted on diabetic patients attending outpatient clinics of the OEMC of King Fahd Medical City during a period of 12 months using Clarke questionnaire. In addition, we assessed the possible determinants of IAH. Objectives: The aim of the current study was to investigate the self-reported prevalence of moderate, severe hypoglycemia, and IAH among patient visiting KFMC Obesity Metabolic Endocrine Centre (OEMC) Type 1 and Type 2 diabetics. At present, no previous study was performed in Saudi Arabia region to ascertain the IAH prevalence. It can result in severe hypoglycemia and possibly death.
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Users should refer to the original published version of the material for the full abstract.Abstract Background: Impaired awareness of hypoglycemia (IAH) is an acquired syndrome in people with insulin-treated diabetes, with a diminished or absent ability to perceive the onset of hypoglycemia. No warranty is given about the accuracy of the copy. However, users may print, download, or email articles for individual use. Copyright of Viruses (1999-4915) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission.The presence of amino acid changes at the N-terminal domain and structural mapping of residues under positive selection at heptad repeat 1 provides better insight into the adaptive evolution of the spike gene and might have a potential role in virus-host tropism and pathogenesis. This study will improve our understanding of the evolution of MERS-CoV, and also highlights the need for enhanced surveillance in humans and dromedaries. The presence of the diversifying selection and the topologies with the structural mapping of residues under purifying selection suggested that codon 1020 might have a role in the evolution of spike gene during the divergence of different lineages. The viral concentration peaked during the first week of illness, and the lower respiratory specimens had higher levels of MERS-CoV RNA. We also determined that the viral loads were significantly (p < 0.001) higher in fatal cases, and virus shedding was prolonged in some fatal cases beyond 21 days. The spike gene showed eight amino acid substitutions, especially between the A1 and B5 lineage, and contained positively selected codon 1020. Recombination analysis showed a potential recombination event in study strains from patients in Saudi Arabia. All the MERS-CoV strains belonged to lineage 5, and showed high sequence homology (99.9%) to 2017 strains. We investigated the evolution of the MERS-CoV spike gene sequences and changes in viral loads over time from patients in Saudi Arabia from 2015–2017. There is no vaccine for MERS and anti-viral treatment is generally not applicable. Abstract: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a lethal zoonotic pathogen circulating in the Arabian Peninsula since 2012.